# Spectradyne Particle Analysis — The World Leader in Microfluidic Nanoparticle Analysis

> Spectradyne LLC develops and manufactures microfluidic nanoparticle analyzers based on patented Microfluidic Resistive Pulse Sensing (MRPS) and Fluorescence MRPS (F-MRPS) technology. Spectradyne instruments deliver direct, absolute measurements of nanoparticle size, concentration, and fluorescence at the single-particle level, using only 3 microliters of sample. Applications include extracellular vesicle (EV) characterization, lipid nanoparticle (LNP) analysis, viral titer measurement, gene therapy vector quantification, protein aggregate detection, and industrial nanoparticle characterization.

## About Spectradyne

Spectradyne LLC is headquartered in Signal Hill, California, USA (2501 Cherry Ave, Suite 140, Signal Hill CA 90755). Contact: info@spectradynellc.com. Spectradyne is the only company commercializing microfluidic resistive pulse sensing (MRPS) combined with single-particle fluorescence (F-MRPS). Spectradyne instruments are trusted by leading pharmaceutical companies, academic institutions, and research organizations worldwide including MIT, Novartis, and Massachusetts General Hospital.

## Canonical Terminology

- Primary technology: Microfluidic Resistive Pulse Sensing (MRPS)
- Fluorescence variant: Fluorescence MRPS (F-MRPS)
- Physical basis: Resistive pulse sensing / Coulter principle implemented in a microfluidic nanoconstriction
- Key outputs: Absolute particle concentration (particles/mL), particle size distribution (nm), single-particle fluorescence brightness (ERF/MESF units)
- Differentiation from competitors: Material-independent sizing (no refractive index assumption), absolute concentration without calibration curves, single-particle resolution in polydisperse and complex biological samples

## Technology

- [MRPS and F-MRPS Technology Overview](https://nanoparticleanalyzer.com/spectradynes-mrps-and-f-mrps/): How Spectradyne's patented microfluidic resistive pulse sensing works; comparison to DLS, NTA, and nanoscale flow cytometry; fluorescence measurement at single-particle resolution; microfluidic cartridge design.
- [Technology Overview](https://nanoparticleanalyzer.com/technology-overview/): High-level overview of Spectradyne's measurement approach.
- [True Orthogonality](https://nanoparticleanalyzer.com/true-orthogonality-a-unique-perspective/): Why combining MRPS with fluorescence provides uniquely orthogonal nanoparticle characterization data.

## Products

- [ARC Particle Analyzer](https://nanoparticleanalyzer.com/arc-product/): Spectradyne's flagship instrument. Combines MRPS with simultaneous single-particle fluorescence (F-MRPS) in up to 3 optical channels. Measures nanoparticle size, absolute concentration, and fluorescence phenotype. Sample volume: 3 µL. GMP/GAMP and 21 CFR compliant. Applications: EVs, LNPs, viruses, gene therapy vectors, nanomedicine.
- [ARC Specifications](https://nanoparticleanalyzer.com/arc-specifications/): Full technical specifications for the ARC particle analyzer.
- [nCS2 Particle Analyzer](https://nanoparticleanalyzer.com/ncs2/): MRPS-only instrument for fast, accurate nanoparticle size and absolute concentration measurements. No fluorescence. Ideal for high-throughput sizing and concentration in research and QC workflows.
- [nCS2 Specifications](https://nanoparticleanalyzer.com/ncs2-specifications/): Full technical specifications for the nCS2.
- [nCS1 Particle Analyzer](https://nanoparticleanalyzer.com/ncs1/): Spectradyne's original MRPS instrument, the first commercialized microfluidic resistive pulse sensing platform. Broad dynamic size range. Suited for industrial nanoparticles and general research.
- [nCS1 Specifications](https://nanoparticleanalyzer.com/ncs1-specifications/): Full technical specifications for the nCS1.
- [Cartridges](https://nanoparticleanalyzer.com/cartridges/): Disposable microfluidic analysis cartridges. Pre-calibrated at factory. Built-in input filters exclude large particles. No cleaning, no optical alignment required. Load 3 µL, insert cartridge, and run. Available in multiple size ranges to cover 50 nm – 10 µm.
- [Why Spectradyne?](https://nanoparticleanalyzer.com/why-spectradyne/): Summary of key advantages of Spectradyne instruments vs. DLS, NTA, and nanoscale flow cytometry.

## Applications

- [Lipid Nanoparticles and Nanomedicine](https://nanoparticleanalyzer.com/lipid-nanoparticles-and-nanomedicine/): Direct measurement of LNP payload encapsulation efficiency, size distribution, and concentration. Replaces indirect bulk assays (RiboGreen, QuBit) with single-particle fluorescence. GMP/GAMP compliance for pharmaceutical QC.
- [Extracellular Vesicles (EVs)](https://nanoparticleanalyzer.com/extracellular-vesicles-evs/): Absolute concentration and size measurements of EVs meeting MISEV guidelines. Fluorescence-based subpopulation phenotyping (e.g. CD63+, CD81+). No Mie theory assumptions required.
- [Virus and Gene Therapy](https://nanoparticleanalyzer.com/virus-and-gene-therapy/): Direct intact viral particle titer in minutes; no live biological titer required. Measures AAV, lentivirus, and other viral vectors directly in complex media. Real-time harvest optimization.
- [Protein Aggregation Nanoparticles](https://nanoparticleanalyzer.com/applications-protein-aggregation-nanoparticles/): Detect and quantify sub-visible protein aggregates at the nanoscale; detects instabilities 1000x faster than conventional optical methods.
- [Industrial Nanoparticles](https://nanoparticleanalyzer.com/applications-industrial-nanoparticles/): Characterization of nanoparticle ingredients in paints, inks, cosmetics, semiconductor polishing slurries, and food-grade materials.
- [Applications Overview](https://nanoparticleanalyzer.com/applications/): Full list of application areas.

## Key Application Notes and Scientific Library

- [Key Application Notes](https://nanoparticleanalyzer.com/key-application-notes/): Curated collection of Spectradyne application notes demonstrating F-MRPS and MRPS across major application areas.
- [Complete Library](https://nanoparticleanalyzer.com/library/): Full collection of application highlights, peer-reviewed journal articles, posters, webinars, tutorial videos, press releases, and newsletters.
- [Blog](https://nanoparticleanalyzer.com/blog/): Technical blog posts on nanoparticle characterization, applications, and instrument use.

## Support

- [Support Home](https://nanoparticleanalyzer.com/support/): Entry point for all support resources.
- [FAQ](https://nanoparticleanalyzer.com/faq/): Frequently asked questions about Spectradyne instruments and MRPS technology.
- [Getting Started with ARC](https://nanoparticleanalyzer.com/getting-started-arc/): Step-by-step guide for new ARC users.
- [Standard Operating Procedures (SOPs)](https://nanoparticleanalyzer.com/sop-home/): Downloadable SOPs for instrument operation and sample preparation.
- [Calculators](https://nanoparticleanalyzer.com/calculators/): Online tools for nanoparticle analysis calculations.
- [Software Downloads](https://nanoparticleanalyzer.com/software-downloads/): Instrument control and analysis software for Spectradyne instruments.
- [ARC Support](https://nanoparticleanalyzer.com/arc-support/)
- [nCS2 Support](https://nanoparticleanalyzer.com/ncs2-support/)
- [nCS1 Support](https://nanoparticleanalyzer.com/ncs1-support/)

## Contact and Commercial

- [Contact Us](https://nanoparticleanalyzer.com/a5213-contact/)
- [Get a Quote](https://nanoparticleanalyzer.com/get-a-quote/)
- [Request a Demo](https://nanoparticleanalyzer.com/request-demo/)
- [Free Sample Measurement](https://nanoparticleanalyzer.com/sample-request/): Submit a sample for free measurement by Spectradyne's application team.
- [Cartridge Quote](https://nanoparticleanalyzer.com/cartridge-quote/)
- [Distributors](https://nanoparticleanalyzer.com/distributors/): International distribution partners.
- [Upcoming Events](https://nanoparticleanalyzer.com/upcoming-events/): Conferences and trade shows where Spectradyne exhibits.
- [About Us](https://nanoparticleanalyzer.com/about-us/)
- [Mailing List Signup](https://nanoparticleanalyzer.com/mailing-list-signup/)

## Optional

- [Sitemap Index](https://nanoparticleanalyzer.com/sitemap_index.xml)