High Resolution Nanoparticle Analysis with the nCS1TM

Nanoparticle analysis done right

The nCS1TM nanoparticle analyzer

instrument

Spectradyne's nCS1 instrument provides a unique platform for the rapid quantitative measurement of nanoparticles in solution. The method used to measure nanoparticles is electrical in nature, so does not rely on an optical index contrast to distinguish particles from their suspending medium. The instrument measures individual nanoparticles and rapidly accumulates statistically-reliable distributions of particle sizes with quantitative concentration information. This unique capability separate the nCS1 from any other instrument on the nanoparticle analysis marketplace.

Watch a video of the nCS1 in action!

Key features of the nCS1TM

  • Resistive pulse sensing and size measurements of individual nanoparticles in fluid
  • Disposable microfluidic cartridge that avoids cross-contamination
  • Reports particle size distribution with absolute concentration
  • Particle sizes: 40 nm to microns in diameter
  • Concentration range: approx. 106 — 1012 particles/mL
  • Max particle detection rate: approx. 10,000 particles/s
  • Nanoparticles of any material type (transparent & opaque, conducting & insulating)
  • Bench-top footprint
  • Line power (110V & 60 Hz | 220 V & 50 Hz)
  • Dimensions: 13" wide × 13" deep × 15" high (330 mm wide × 330 mm deep × 380 mm high)
  • Weight: 30 lbs (14 kg)
  • Instrument control interface: USB to Windows

Software

  • Proprietary signal extraction method
  • Streamlined process flow
  • Multi-dimensional data visualization
  • Rapid concentration measurements in any measured size range
  • Automated particle distribution analysis

Microfluidic cartridges

Spectradyne's nCS1 instrument relies on nanofabricated disposable analysis cartridges. These microfluidic devices are based on a unique patented nanoparticle analyzer (NPA) technology that uses resistive pulse sensing. This enables the electrical detection of nanoparticles as they pass one by one through a nanoconstriction. A single nanoparticle increases the electrical resistance of the suspending fluid as it passes through the nanoconstriction, giving rise to a voltage pulse whose size is proportional to the nanoparticle volume and whose duration of the pulse gives the velocity.

Different size cartridges give access to different size ranges of nanoparticles, ranging from 40 nm in diameter up to several micrometers.

In the table below we display the different cartridge specifications that are available.

Read about our microfluidic technology.

cartridges
Part number Size range
TS-300 50-300 nm particle diameters
TS-400 65-400 nm particle diameters
TS-2000 200-2000 nm particle diameters

Starter Kits

We can provide starter kits for researchers just starting out with our instrument.

nCS1 Starter Kit - Basic

  • nCS1 Cleaning Cartridge
  • nCS1 Measurement Cartridges: TS-300, TS-400 and TS-2000
  • Tween-20 surfactant
  • Phosphate buffered saline 10×
  • Calibrated nanoparticles: 150 nm, 208 nm, 505 nm and 1240 nm diameters
  • Whatman 20 nm and 200 nm syringe filters
  • 3 mL and 5 mL Luer syringes, plastic
  • Allen key set


nCS1 Starter Kit - Deluxe

All items in the nCS1 Starter Kit - Basic, plus:

  • Portable air compressor & fittings
  • Set of calibrated micropipettes & pipette carousel
  • Micropipette tips
  • Microcentrifuge tubes & holder
  • Minivortexer
  • Minicentrifuge

Concentration Spectral Density

csd

Software generates histograms of particle diameters, yielding the concentration spectral density (CSD) with units of nanoparticles per unit volume per unit diameter (particles-mL-1-nm-1). This quantitative measure can easily be converted to histograms representing the number of particles in any desired bin width; the CSD is a measurement-independent property of the analyte. Good statistics can be obtained in a few seconds. A more technical description of the measurement platform may be found in J.-L. Fraikin et al., Nature Nanotechnology (2011).

Particles of any material

Spectradyne's nCS1 provides accurate, high-resolution particle size and concentration distributions for particles of all material types. The use of resistive pulse sensing for detecting the particle size responds the same way when presented with particles of biological, organic or inorganic origin, giving e.g. the same result for gold NPs, virus and lipids of the same diameter. For more information or to arrange a demonstration of the technology, please contact us.

particles

Want to see more?

We're happy to do demonstrations, or measure your samples.
To find out more, send an email to info@spectradynellc.com or:

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