Compare › Spectradyne’s MRPS and F-MRPS
MRPS technology overview
Spectradyne’s microfluidic resistive pulse sensing: true nanoparticle size and concentration, without the guesswork
Fast, affordable, and easy to use, Spectradyne’s MRPS and F-MRPS technology — a patented microfluidic implementation of resistive pulse sensing (aka the Coulter principle) — delivers direct and accurate measurements of nanoparticle size and concentration, even in complex, heterogeneous samples.
MRPS is an electrical particle analysis technique that is fundamentally different from run-of-the-mill light scattering-based methods such as dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), or nanoscale flow cytometry (nanoFCM). It delivers a fresh perspective and new insights that cannot be obtained from conventional optical methods.
MRPS delivers the most direct measurements of size and concentration at the nanoscale — true particle sizing that is independent of sample polydispersity or refractive index. Read the original Nature Nanotechnology publication here.
Technology
True nanoparticle size and concentration
MRPS was first commercialized in Spectradyne’s nCS1™ particle analyzer and is the core technology inside all of Spectradyne’s analytical instruments.
It delivers a fresh perspective and new insights that cannot be obtained from conventional optical methods — measuring each particle electrically, one at a time, rather than inferring a distribution from bulk light scattering.
Validation
Gold-standard accuracy, without the time and cost
In a collaboration with NanoImaging Services (NIS), we compared measurements of lipid nanoparticles using the gold standard for nanoparticle size and concentration, Cryo-TEM, against our MRPS systems.
Our data show excellent correlation, and illustrate how our F-MRPS and MRPS systems can provide unparalleled accuracy quickly and easily.
Download the Cryo-TEM Validation Application NoteFluorescence
And now with fluorescence: F-MRPS
Spectradyne’s ARC™ particle analyzer uniquely combines MRPS with simultaneous measurements of single-particle fluorescence to enable all kinds of new science — size, concentration, and cargo quantification in one run.
Whether you’re measuring lipid nanoparticle encapsulation efficiency, phenotyping EVs, or quantifying viral titer for gene therapy production, F-MRPS gets you there without bulk assays or optical assumptions. See how it applies to your work below.
See the ARC particle analyzer specifications
Cartridges
Microfluidics make your life easier
Spectradyne’s patented microfluidic analysis cartridges are engineered to help you get the data you need, faster. Easily analyze complex, real-world samples like biofluids or nanomedicines in biofluids without a sample cleanup step — a built-in filter excludes large particles before they reach the sensing constriction.
Cartridges ship pre-calibrated from the factory with no optical alignment required, need just 3 microliters of sample, and require no purging or cleaning between samples.
Learn more about our cartridgesApplications
Find the right fit for your work
See the power of Spectradyne’s technology for yourself