Technology

Why choose Spectradyne?

Spectradyne’s MRPS and F-MRPS technology delivers direct, single-particle measurements that optical techniques simply can’t match. See how we compare head-to-head.

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The comparisons on this and following pages draws on peer-reviewed data from a Johns Hopkins University study published in the Journal of Extracellular Vesicles (Arab et al., 2021) that compared four orthogonal single-particle platforms — MRPS, NTA, nanoFCM, and SP-IRIS — across both synthetic and biological EV samples, as well as a Bristol-Myers Squibb research paper published in Pharmaceutical Research (Barnett et al., 2018) that compared submicron protein particle characterization using resistive pulse sensing against conventional light scattering techniques.

Head-to-head comparisons

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Technology comparison

MRPS vs DLS vs NTA

How Spectradyne’s microfluidic resistive pulse sensing compares to conventional optical techniques across the measurements that matter most.

	Spectradyne MRPS	DLS	NTA

View plain text data table

Category	Spectradyne MRPS	DLS	NTA
Calibration needed?	No calibration required	Yes — a standard must be run before each new cuvette	Yes — system cleanliness must be ensured before each measurement
Direct measurement of size?	Yes — particle size is the primary measurement	No — size inferred from fluctuations in light correlation	No — size inferred from observed Brownian motion
Particle distribution resolution	High — resolves polydisperse distributions precisely	Low — large particles dominate and distort the measurement	Moderate — sensitivity varies with refractive index and polydispersity
Impact of polydispersity	None — any polydispersity is acceptable	Significant — strongly biased towards large particles	Significant — sensitivity and limit of detection vary with polydispersity
Sample volume required	Very low — only 3 µL required	Varies — 50 to 1,500 µL depending on cuvette	High — minimum of 100 µL required
Direct measurement of concentration?	Yes — measured particle count divided by measured sample volume	No — complex conversion of light scattering to concentration	No — measured particle count divided by estimated imaging volume
Dependence on particle material	None — no material assumptions required	Significant — refractive index, viscosity, shape, and temperature all required	Significant — range of scattering intensities, viscosity, shape, and temperature affect results