Measurement of mRNA payload in Lipid Nanoparticles (LNPs) with Spectradyne’s ARC™ Particle Analyzer
Three LNP formulations were prepared using different preparation conditions. All were loaded with an mRNA payload.
The RNA payload was fluorescently labeled with a membrane-permeable intercalating nucleic acid stain according to manufacturer’s instructions. Particle size, concentration and fluorescence were measured using Spectradyne’s ARC particle analyzer.
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