High Resolution Particle Size Analysis with the nCS1TM

Nanoparticle size analysis done right

The nCS1TM particle size analyzer


Spectradyne's nCS1 instrument provides a unique platform for the rapid quantitative measurement of nanoparticles in solution. The method used to perform particle size analysis is electrical in nature, so does not rely on an optical index contrast to distinguish particles from their suspending medium. The instrument measures individual nanoparticles and rapidly accumulates statistically-reliable distributions of particle sizes with quantitative concentration information. This unique capability separate the nCS1 from any other instrument on the particle size analysis marketplace.

See an overview of Spectradyne's unique technology, incorporating disposable microfluidic cartridges and yielding quantitative concentrations versus particle diameters over a wide range of sizes.

Read about the specifications for Spectradyne's nCS1TM, showing the range of particle sizes, concentrations and sample properties that you can measure with this unique technology.

Watch a video of the nCS1 in action!


Read our two-page brochure on the Spectraydne nCS1TM

Key features of the nCS1TM

nCS1TM instrument

  • Resistive pulse sensing and size measurements of individual nanoparticles in fluid
  • Particle size distribution with absolute concentration
  • Particle size analysis range: 50 nm to 10 μm in diameter
  • Concentration range: approx. 104 — 1012 particles/mL
  • Max particle detection rate: approx. 10,000 particles/s
  • Nanoparticles of any material type (transparent & opaque, conducting & insulating)
  • Bench-top footprint
  • Line power (110V & 60 Hz | 220 V & 50 Hz)
  • Dimensions: 13" wide × 15" deep × 13" high (330 mm wide × 380 mm deep × 330 mm high)
  • Weight: 30 lbs (14 kg)
  • Instrument control interface: USB to Windows

Microfluidic cartridges

  • Single-use disposable cartridges
  • No cross-contamination between samples
  • No time-consuming cleaning in between samples
  • 3 μliter sample per use
  • Particle size analysis range from 50 nm to 10 μm in diameter


  • Proprietary signal extraction method
  • Streamlined process flow
  • Multi-dimensional data visualization
  • Rapid concentration measurements in any measured size range
  • Automated particle size analysis

Read more about Spectradyne's nCS1 and its MRPS technology

  • [PDF] A two-page brochure giving an overview of Spectradyne's unique microfluidic resistive pulse sensing analysis technology
  • [PDF] An overview of how Spectradyne's unique microfluidic technology is applied to nanoparticle analysis
  • [PDF] A two-page brochure showing how Spectradyne's technology can be used to characterize liposomes and lipid nanoparticles (LNPs)
  • [PDF] A two-page brochure on using Spectradyne's nCS1TM for measuring extracellular vesicles (EVs)
  • [PDF] Spectradyne's technology yields accurate measurements of broad particle distributions, unlike optically-based techniques
  • [PDF] Spectradyne's technology yields materials-independent measurements of nanoparticles made of gold, polystyrene, or other organic and inorganic materials

How Spectradyne makes every particle count

Spectradyne's nCS1TM uses microfluidic technology combined with nanotechnology to detect and measure every particle in your formulation. We have developed a unique implementation of microfluidic resistive pulse sensing (MRPS), which uses electrical sensing to measure the diameter of each particle as it passes through a nanoconstriction, providing real-time sizing and concentration information.

Read about our microfluidic instrumentation.

Microfluidic cartridges

Spectradyne's technology uses highly-engineered microfluidic cartridges for sample particle size analysis. Leveraging advances in semiconductor processing techniques, these cartridges include engineered features that make the Resistive Pulse Sensing technique practical and easy to use at the nanoscale. Some of the benefits our customers appreciate include: 1000-fold smaller sample volume required for analysis (only 3 microliters), no time spent cleaning flow cells between samples, and embedded fluidic features in each cartridge that prevent the clogging behaviors seen in other simplistic implementations of the method. Pre-calibrated at the factory so you don't have to, the microfluidic analysis cartridges are at the heart of Spectradyne's technology.

In the table below we display the different cartridge specifications that are available for particle size analysis. You can also view a cartridge map for cartridge selection.

Read about our microfluidic technology.

particle size analysis cartridges

Available microfluidic cartridge sizes:

Microfluidic cartridges come in different two formats:

  • TS- format for nCS1TM hardware version 0
  • C- format for nCS1TM hardware version 1
If you're not sure what type you need, read this note.

Part number Size range
C-300/TS-300 50-300 nm particle diameters
C-400/TS-400 65-400 nm particle diameters
C-900/TS-900 130-900 nm particle diameters
C-2000/TS-2000 250-2000 nm particle diameters
C-10k/TS-10k 1,500-10,000 nm (1.5-10 micron) particle diameters
particle size analysis cartridge map

Want to learn more?

Click here to view a webinar on our technology.

We discuss the nCS1 technology and present detailed measurement results.

Starter Kits

nCS1 Starter Kit - Basic

  • SFKit-0.02 (10 syringes and filters, 0.02 μm)
  • SFKit-0.2 (10 syringes and filters, 0.2 μm)
  • Calibrated nanoparticles (1.0 mL each): 150 nm, 208 nm, 505 nm, 1240 nm in diameter
  • Phosphate buffered saline 10× (1000 mL)
  • Tween-20 (100 mL)

nCS1 Starter Kit - Deluxe

  • SFKit-0.02 (10 syringes and filters, 0.02 μm)
  • SFKit-0.2 (10 syringes and filters, 0.2 μm)
  • Calibrated nanoparticles (1.0 mL each): 150 nm, 208 nm, 505 nm, 1240 nm in diameter
  • Phosphate buffered saline 10× (1000 mL)
  • Tween-20 (100 mL)
  • One set of three calibrated micropipettes (20 μL, 200 μL, 1000 μL) and a pipette carousel
  • Two boxes of micropipette tips (96 tips per box): 20 μL, 200 μL, 1000 μL tips
  • One box of 500 1.5 mL microcentrifuge tubes and holder
  • Minivortexer
  • Minicentrifuge

Interested in pricing?

Send an email to sales@spectradynellc.com or click here to access a quote form.

Concentration Spectral Density

particle size analyzer CSD

Software generates histograms of particle diameters, yielding the concentration spectral density (CSD) with units of nanoparticles per unit volume per unit diameter (particles-mL-1-nm-1). This quantitative measure can easily be converted to histograms representing the number of particles in any desired bin width; the CSD is a measurement-independent property of the analyte. Good statistics can be obtained in a few seconds. A more technical description of the measurement platform may be found in J.-L. Fraikin et al., Nature Nanotechnology (2011).

Particle Size Analysis of any material

Spectradyne's nCS1 provides accurate, high-resolution particle size analysis and concentration distributions for particles of all material types. The use of resistive pulse sensing for detecting the particle size responds the same way when presented with particles of biological, organic or inorganic origin, giving e.g. the same result for gold NPs, virus and lipids of the same diameter. For more information or to arrange a demonstration of our particle size analysis technology, please contact us.

particle size analyzer particles

Want to see more?

We're happy to do demonstrations, or measure your samples.
To find out more, send an email to info@spectradynellc.com or:

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