Spectradyne's nCS1 instrument provides a unique platform for the rapid quantitative measurement of nanoparticles in solution. The method used to measure nanoparticles is electrical in nature, so does not rely on an optical index contrast to distinguish particles from their suspending medium. The instrument measures individual nanoparticles and rapidly accumulates statistically-reliable distributions of particle sizes with quantitative concentration information. This unique capability separate the nCS1 from any other instrument on the nanoparticle analysis marketplace.
See an overview of Spectradyne's unique technology
Watch a video of the nCS1 in action!
We discuss the nCS1 technology and present detailed measurement results.
Spectradyne's nCS1 instrument relies on nanofabricated disposable analysis cartridges. These microfluidic devices are based on a unique patented nanoparticle analyzer (NPA) technology that uses resistive pulse sensing. This enables the electrical detection of nanoparticles as they pass one by one through a nanoconstriction. A single nanoparticle increases the electrical resistance of the suspending fluid as it passes through the nanoconstriction, giving rise to a voltage pulse whose size is proportional to the nanoparticle volume and whose duration of the pulse gives the velocity.
Different size cartridges give access to different size ranges of nanoparticles, ranging from 40 nm in diameter up to several micrometers.
In the table below we display the different cartridge specifications that are available. You can also view a cartridge map for cartridge selection.
Read about our microfluidic technology.
All items in the nCS1 Starter Kit - Basic, plus:
Software generates histograms of particle diameters, yielding the concentration spectral density (CSD) with units of nanoparticles per unit volume per unit diameter (particles-mL-1-nm-1). This quantitative measure can easily be converted to histograms representing the number of particles in any desired bin width; the CSD is a measurement-independent property of the analyte. Good statistics can be obtained in a few seconds. A more technical description of the measurement platform may be found in J.-L. Fraikin et al., Nature Nanotechnology (2011).
Spectradyne's nCS1 provides accurate, high-resolution particle size and concentration distributions for particles of all material types. The use of resistive pulse sensing for detecting the particle size responds the same way when presented with particles of biological, organic or inorganic origin, giving e.g. the same result for gold NPs, virus and lipids of the same diameter. For more information or to arrange a demonstration of the technology, please contact us.