spectradyne arc nanoparticle analyzer

The ArcTM particle analyzer delivers:

  • Simultaneous particle size, concentration & fluorescence-based phenotyping
  • Electrical & optical: Simultaneous orthogonal measurements
  • Direct particle size measurements
  • Quantitative fluorescence
  • Compatible with traditional dyes & staining protocols
  • Absolute concentration & size via microfluidic resistive pulse sensing (MRPS)
  • Microliter sample sizes
Accurately quantify particle sub-populations in complex samples in minutes using Spectradyne's Arc

The Arc particle analyzer simultaneously measures single-particle fluorescence in up to three optical channels while leveraging the proven strengths of microfluidic resistive pulse sensing (MRPS) to quantify size and absolute concentration. The result: Fast and accurate quantification of target populations in the most challenging biological samples.


Read our two-page brochure on the Spectraydne ARCTM

Watch a video introduction to the ARC technology.

Read the specifications for the Arc particle analyzer.

Watch a virtual demo of the ARC in action.

Key features of the ArcTM

Arc instrument

  • Single-particle fluorescence-based phenotyping
  • Up to 3 optical detection bands (user configurable)
  • 488 nm default excitation wavelength
  • Absolute concentration & size by Microfluidic Resistive Pulse Sensing (MRPS)
  • Fast measurements: Results in minutes
  • Simple workflow: Use standard fluorescence labelling protocols
  • Small bench-top footprint

Microfluidic cartridges

  • Single-use disposable cartridges
  • No cross-contamination between samples
  • No time-consuming cleaning in between samples
  • 3 μliter sample per use
  • Particle size analysis range from 50 nm to 2 μm in diameter
  • Concentration range: 104 — 1012 particles/mL


  • Proprietary signal extraction method
  • Streamlined process flow
  • Multi-dimensional data visualization
  • Rapid concentration measurements in any measured size range
  • Automated particle size analysis

How Spectradyne makes every particle count

Spectradyne's ArcTM uses microfluidic technology combined with fluorescent imaging to detect the fluorescent signal and measure the size of each particle in your formulation. This unique combination yields phenotyping and electrically-based particle sizing of each particle as it passes through a nanoconstriction, so that you know the particle type as well as size plus concentration information.

Read about our microfluidic instrumentation.

Microfluidic cartridges

Spectradyne's technology uses highly-engineered microfluidic cartridges for sample particle size analysis. Leveraging advances in semiconductor processing techniques, these cartridges include engineered features that make the Resistive Pulse Sensing technique practical and easy to use at the nanoscale. Some of the benefits our customers appreciate include: 1000-fold smaller sample volume required for analysis (only 3 microliters), no time spent cleaning flow cells between samples, and embedded fluidic features in each cartridge that prevent the clogging behaviors seen in other simplistic implementations of the method. Pre-calibrated at the factory so you don't have to, the microfluidic analysis cartridges are at the heart of Spectradyne's technology.

In the table below we display the different cartridge specifications that are available for particle size analysis. You can also view a cartridge map for cartridge selection.

Read about our microfluidic technology.

particle size analysis cartridges

Available microfluidic cartridge sizes:

Microfluidic cartridges come in different two formats:

  • C- format for nCS1TM hardware version 1 (standard)
  • TS- format for nCS1TM hardware version 0 (not common)
If you're not sure what type you need, read this note.

Part number Size range
C-300/TS-300 50-300 nm particle diameters
C-400/TS-400 65-400 nm particle diameters
C-900/TS-900 130-900 nm particle diameters
C-2000/TS-2000 250-2000 nm particle diameters
C-10k/TS-10k 1,500-10,000 nm (1.5-10 micron) particle diameters
particle size analysis cartridge map

Which technology is right for me?


Fast & accurate particle analysis with MRPS


MRPS plus single-particle fluorescence phenotyping

Want to learn more?

Click here to see a video on the ARC technology.

Starter Kits

We can provide starter kits for researchers just starting out with our particle size analyzer.

nCS1 Starter Kit - Basic

  • nCS1 Cleaning Cartridge
  • nCS1 Measurement Cartridges: TS-300, TS-400 and TS-2000
  • Tween-20 surfactant
  • Phosphate buffered saline 10×
  • Calibrated nanoparticles: 150 nm, 208 nm, 505 nm and 1240 nm diameters
  • Whatman 20 nm and 200 nm syringe filters
  • 3 mL and 5 mL Luer syringes, plastic
  • Allen key set

nCS1 Starter Kit - Deluxe

All items in the nCS1 Starter Kit - Basic, plus:

  • Portable air compressor & fittings
  • Set of calibrated micropipettes & pipette carousel
  • Micropipette tips
  • Microcentrifuge tubes & holder
  • Minivortexer
  • Minicentrifuge

Interested in pricing?

Send an email to sales@spectradynellc.com or click here to access a quote form.

Concentration Spectral Density

particle size analyzer CSD

Software generates histograms of particle diameters, yielding the concentration spectral density (CSD) with units of nanoparticles per unit volume per unit diameter (particles-mL-1-nm-1). This quantitative measure can easily be converted to histograms representing the number of particles in any desired bin width; the CSD is a measurement-independent property of the analyte. Good statistics can be obtained in a few seconds. A more technical description of the measurement platform may be found in J.-L. Fraikin et al., Nature Nanotechnology (2011).

Particle size analysis of any material

Spectradyne's Arc provides multi-channel fluorescence combined with accurate, high-resolution particle size analysis for particles of all material types. The data shows you both the phenotyping characterisics and the size of each individual particle. The Arc responds the same way when presented with particles of biological, organic or inorganic origin.

For more information or to arrange a demonstration of our particle size analysis technology, please contact us.

particle size analyzer particles

Want to see more?

We're happy to do demonstrations, or measure your samples.
To find out more, send an email to info@spectradynellc.com or:

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