High Resolution Particle Size Analysis with the nCS1TM
Nanoparticle size analysis done right
The nCS1TM particle size analyzer
Spectradyne's nCS1 instrument provides a unique platform for the rapid quantitative measurement of nanoparticles in solution. The method used to perform particle size analysis is electrical in nature, so does not rely on an optical index contrast to distinguish particles from their suspending medium. The instrument measures individual nanoparticles and rapidly accumulates statistically-reliable distributions of particle sizes with quantitative concentration information. This unique capability separate the nCS1 from any other instrument on the particle size analysis marketplace.
See an overview of Spectradyne's unique technology, incorporating disposable microfluidic cartridges and yielding quantitative concentrations versus particle diameters over a wide range of sizes.
Read about the specifications for Spectradyne's nCS1TM, showing the range of particle sizes, concentrations and sample properties that you can measure with this unique technology.
Max particle detection rate: approx. 10,000 particles/s
Nanoparticles of any material type (transparent & opaque, conducting & insulating)
Line power (110V & 60 Hz | 220 V & 50 Hz)
Dimensions: 13" wide × 13" deep × 15" high (330 mm wide × 330 mm deep × 380 mm high)
Weight: 30 lbs (14 kg)
Instrument control interface: USB to Windows
Single-use disposable cartridges
No cross-contamination between samples
No time-consuming cleaning in between samples
3 μliter sample per use
Particle size analysis range from 50 nm to 10 μm in diameter
Proprietary signal extraction method
Streamlined process flow
Multi-dimensional data visualization
Rapid concentration measurements in any measured size range
Automated particle size analysis
Read more about Spectradyne's nCS1 and its MRPS technology
[PDF] A two-page brochure giving an overview of Spectradyne's unique microfluidic resistive pulse sensing analysis technology
[PDF] An overview of how Spectradyne's unique microfluidic technology is applied to nanoparticle analysis
[PDF] A two-page brochure showing how Spectradyne's technology can be used to characterize liposomes and lipid nanoparticles (LNPs)
[PDF] A two-page brochure on using Spectradyne's nCS1TM for measuring extracellular vesicles (EVs)
[PDF] Spectradyne's technology yields accurate measurements of broad particle distributions, unlike optically-based techniques
[PDF] Spectradyne's technology yields materials-independent measurements of nanoparticles made of gold, polystyrene, or other organic and inorganic materials
How Spectradyne makes every particle count
Spectradyne's nCS1TM uses microfluidic technology combined with nanotechnology to detect and measure every particle in your formulation. We have developed a unique implementation of microfluidic resistive pulse sensing (MRPS), which uses electrical sensing to measure the diameter of each particle as it passes through a nanoconstriction, providing real-time sizing and concentration information.
Spectradyne's technology uses highly-engineered microfluidic cartridges for sample particle size analysis. Leveraging advances in semiconductor processing techniques, these cartridges include engineered features that make the Resistive Pulse Sensing technique practical and easy to use at the nanoscale. Some of the benefits our customers appreciate include: 1000-fold smaller sample volume required for analysis (only 3 microliters), no time spent cleaning flow cells between samples, and embedded fluidic features in each cartridge that prevent the clogging behaviors seen in other simplistic implementations of the method. Pre-calibrated at the factory so you don't have to, the microfluidic analysis cartridges are at the heart of Spectradyne's technology.
In the table below we display the different cartridge specifications that are available for particle size analysis. You can also view a cartridge map for cartridge selection.
Software generates histograms of particle diameters, yielding the concentration spectral density (CSD) with units of nanoparticles per unit volume per unit diameter (particles-mL-1-nm-1). This quantitative measure can easily be converted to histograms representing the number of particles in any desired bin width; the CSD is a measurement-independent property of the analyte. Good statistics can be obtained in a few seconds. A more technical description of the measurement platform may be found in J.-L. Fraikin et al., Nature Nanotechnology (2011).
Particle Size Analysis of any material
Spectradyne's nCS1 provides accurate, high-resolution particle size analysis and concentration distributions for particles of all material types. The use of resistive pulse sensing for detecting the particle size responds the same way when presented with particles of biological, organic or inorganic origin, giving e.g. the same result for gold NPs, virus and lipids of the same diameter. For more information or to arrange a demonstration of our particle size analysis technology, please contact us.
Want to see more?
We're happy to do demonstrations, or measure your samples. To find out more, send an email to email@example.com or:
Spectradyne is a world leader in the microfluidic measurement of nanoparticles.
Nanoparticle analysis using resistive pulse sensing avoids many of the difficulties associated with DLS and optical tracking. Spectradyne is the only company providing microfluidic particle size analysis.