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Spectradyne Newsletter #14

February 2022

nanoparticles in pharmaceuticals

Recent publications using Spectradyne’s instruments


Find these new papers and many others in the Refereed Journal Articles section of our Library:

  • Researchers in the Biological Nanochemistry Research Group at the Research Centre for Natural Resources in Hungary use microfluidic resistive pulse sensing (MRPS) to follow the changes in the size distribution of extracellular vesicles (EVs) under different storage conditions and times, using Spectradyne’s nCS1TM. Find the article in Nature’s Scientific Reportshere.
  • Scientists from NIST Gaithersburg, Bristol-Myers Squibb, FDA, Lonza, Spectradyne and other companies explore a joint effort to characterize sub-micron particle dispersions using a range of different characterization methods, including using Spectradyne’s nCS1TM. Read this broad comparison study in the Journal of Pharmaceutical Scienceshere.
  • Researchers at the Cleveland Clinic demonstrate a scalable method for isolating and purifying extracellular vesicles from bacteria, validating their process using Spectradyne’s nCS1TM. You can find a version of their paper on JOVE’s video website here.

Shows and Events


Upcoming events that you can register for:

  • Ready for a technology deep-dive? Join our webinar on Wednesday February 23, 2022, at 10 am Pacific, to learn what are the best practices for characterizing lipid nanoparticles (LNPs), extracellular vesicles (EVs) and other biological particles. Register here!
  • Join us at Select Bio’s Circulating Biomarkers Europe, 1-2 March 2022 in Rotterdam, The Netherlands. Spectradyne will present “Trends in EV Characterization Technologies” on Tuesday, March 1, 2022 at 10 am Eastern time.

Recent events you can still watch by streaming from our library:

  • What have we learned in our field experience with scientists studying lipid nanoparticles (LNPs)? Listen to Spectradyne’s East Coast sales representative share stories from the field in this webinar: “Revealing the true character of drug delivery vehicles at the nanoscale – Current best practices for measuring the size and concentration of lipid nanoparticles (LNPs).”
  • In December, Spectradyne proudly sponsored the scientific conference, “Extracellular Vesicles (EVs): Technologies and Biological Investigations,” hosted by SelectBIO on Coronado Island, CA. Listen to our presentation entitled, “Insights into EV Characterization Technologies” delivered by Spectradyne’s CEO Jean-Luc Fraikin.



New additions to our blog

Last year we asked, “What’s in a COVID vaccine?” We answered this ourselves by using the nCS1 to quantify the particle size distribution in one of two popular mRNA vaccines. Now we’ve done it again, characterizing the other commonly-available mRNA vaccine! You can find the results of the second measurement, and a comparison to the first one, in this recent post: “How does the other mRNA COVID vaccine compare?”

Ever work with red blood cells (RBCs?) Ever wonder how to store them in a stable way that limits the production of harmful extracellular vesicles (EVs)? Read our summary of a new paper in Nature’s Scientific Reports, in which Spectradyne’s technology was used to quantify the EVs produced by RBCs stored in different conditions and media. Cool experiment!

Visit our main blog page to find these and other posts we hope you find interesting — happy reading!



New videos in our library

Recent additions to our video library focus on two areas: Applications of Spectradyne’s technology for quantifying lipid nanoparticles (LNPs), and a hands-on tutorial explaining how to load and operate Spectradyne’s analysis cartridges.