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nCS1’s Large Dynamic Range for Diverse Applications

August 23, 2019 – Large dynamic range for diverse applications

We love learning from our customers about the science of their materials, and because the nCS1TM can measure any particle type equally well, we get to learn about a very wide range of applications.

For example, scientists routinely use Spectradyne’s nCS1TM to assess drug formulation stability, to quantify extracellular vesicles (EVs) and exosomes, to characterize lipid nanoparticles and emulsions, to titer viruses for gene therapy applications, and to characterize new industrial nanomaterials.

One analytical requirement shared by all of these applications is to be able to measure particles across a broad range of sizes and concentrations. In Spectradyne’s experience, biological samples – be they biologic drugs, urinary vesicles, cell culture media, or serum – tend to be highly polydisperse (regardless of what DLS tells you!). Measuring concentration accurately in such samples is difficult, and we argue that Spectradyne’s nCS1TM is the only technology available that does so. It’s critical to have this information if a material is to be accurately characterized: At right we show the measurement of a single product that contains vesicles spanning 60 nm to 6 microns in diameter and nearly 9 orders of magnitude in concentration! Particle function depends critically on particle size, and the broad dynamic range of Spectradyne’s nCS1TM allows a researcher to get a complete and accurate picture of what’s in the sample to better understand how it will work.

Our customers frequently tell us how happy they are with the nCS1’s dynamic range, which spans from 50 nanometers to 10 microns in diameter, and from 104/mL to 1012/mL in concentration. To see the complete picture of what’s in your sample, send us samples for a free analysis, or contact us today to arrange a demonstration.

extracellular vesicles

nCS1TM analysis of a sample containing a broad range of vesicle sizes and concentrations.

Please continue to follow our blog as we share insights, technical details, and generally geek-out with you about nanoparticle science!

Email us for more information, or to discuss your particular application directly.