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Spectradyne Newsletter #12

July 2021

nanoparticles in pharmaceuticals



What’s in a (COVID) vaccine?

The whole world is getting it — ever wonder what’s in it? We got our hands on a residual 3 μL of one of the major 2-dose vaccines, check out what we found!

Recent publications using Spectradyne’s instruments


Methods for characterizing EVs and synthetic nanoparticles

Researchers from Johns Hopkins University and the National Institute of Standards and Technology published a thorough study comparing four technologies for characterizing extracellular vesicles (EVs) and synthetic nanoparticles. Learn how Spectradyne’s Microfluidic Resistive Pulse Sensing (MRPS) stacks up against Nanoparticle Tracking Analysis (NTA), Nanoflow Cytometry Measurement (NFCM) and Single-particle Interferometric Reflectance Imaging (SP-IRIS) in the Journal of Extracellular Vesicles, here.

Characterizing complex biofluids

Scientists at the University of Amsterdam at AMC and the Research Center for Natural Sciences developed standard methods and operating protocols for measuring complex biofluids with Spectradyne’s nCS1TM instrument. Read about it in PLOS One, here.

Purifying extracellular vesicles (EVs)

Our favorite Australian customer, Exopharm Pty Ltd., published the long-anticipated details of their commercial process for purifying extracellular vesicles for therapeutic applications. Spectradyne’s nCS1TM features prominently as a metrology used to characterize and monitor this process, which is called Ligand-Based Exosome Affinity Purification (LEAP). The process is scalable to high throughput and therefore delivers a viable solution to a critical scale-up bottleneck for the practical commercialization of EV-based therapeutics in the future.

Controlling EV concentration

Researchers at Case Western Reserve University demonstrated that extracellular vesicles (EVs) generated in SARS-CoV-2-infected cells can carry the SARS-CoV-2 spike protein and block therapeutic antibodies. The scientists used Spectradyne’s nCS1 to control for EV concentration — a critical experimental variable — in comparison tests of the biological activity of different EV preparations. This use case is a textbook example of how good metrology can lead to better science! Read in more detail here.

Please let us know what you think!

Video library


New videos in our library

A key strength of Spectradyne’s MRPS technology is that particles are measured independently from one another. This permits powerful science, including the ability to create built-in positive controls for each measurement using standards for size and concentration spiked directly into the sample. Learn about calibration methods in this new video!

Recent and Upcoming Conferences & Exhibits


Recent and upcoming conference presentations and exhibits

In the second quarter of 2021, Spectradyne proudly sponsored the 2021 annual meeting of the American Society of Gene & Cell Therapy, and the International Society for Extracellular Vesicles 2021 meeting, both of which were held virtually. In July Spectradyne will sponsor the 37th International Symposium on Microscale Separations and Bioanalysis (MSB) 2021, usually held in Boston MA.

We hope to “see” you there!