Skip to content

Spectradyne Newsletter #15

May 2022

nanoparticles in pharmaceuticals



New software-based technology enhancements – Dynamic concentration analysis and more

Spectradyne is proud to announce the deployment of Dynamic Concentration Analysis, an improved method for calculating nanoparticle concentration by microfluidic resistive pulse sensing (MRPS). Briefly, the new method delivers more accurate measurements of the sample volume in which particles are detected, particularly in non-standard use cases. Read the full details in this technical brief.
The latest version of Spectradyne tools, version, includes the new Dynamic Concentration Analysis feature, as well as other significant improvements for usability based on input from users:

  • Faster priming routines for both cartridge and instrument
  • Live parametric plots of transit time vs. diameter viewable during data acquisition

Download and install the latest version of Spectradyne Tools to start taking advantage of these new features!

Recent publications


Recent publications from our library:

Find these new papers and many others in the Refereed Journal Articles section of our Library:

  • Dana Al Sulaiman, Nidhi Juthani, and Patrick S. Doyle from the Massachusetts Institute of Technology used Spectradyne’s nCS1 to quantify extracellular vesicles (EVs) in their recent paper, “Quantitative and Multiplex Detection of Extracellular Vesicle-Derived MicroRNA via Rolling Circle Amplification within Encoded Hydrogel Microparticles,” in the journal Advanced Healthare Materials. The authors include a detailed comparison of Spectradyne’s microfluidic resistive pulse sensing (MRPS) and nanoparticle tracking analysis, concluding for reasons we’ve discussed at length on our blog that MRPS is the more accurate measure of EV size and concentration of the two. Read the full open-access article here.
  • In their recent paper in the journal Materials, Mohammed A. Al-Khafaji et al., from the Research Center for natural Sciences in Hungary, optimized a chemical method for fluorescently labeling hollow organosilica nanoparticles. The authors used Spectradyne’s MRPS technology to measure the size and concentration of the labeled particles, and in turn quantify the extent to which fluorochromes were loaded on the particles. Read the full text of the article here.

Shows and Events


In-person events:

  • Spectradyne exhibited at AAPS-National Biotech Conference in Anaheim, May 8-12. It was a lively event and we were glad for the opportunity to see some of you in person!
  • Our European distributor, Anasysta e.K. will be at the APV Workshop on Protein Aggregation and Immunogenicity, May 31-June 1 in Eimeldingen, Germany.

Recent events you can stream from our Library:

  • Ready to discuss the nuts and bolts? Check out our on-demand webinar entitled, “Particle Analysis Technology Deep Dive-How is that black box really measuring my Lipid Nanoparticles (LNPs) or Extracellular Vesicles (EVs)?” to learn about the best practices for characterizing these and other biological particles.
  • View the presentation that kicked off a lively discussion at Select Bio’s Circulating Biomarkers Europe, 1-2 March 2022 in Rotterdam, The Netherlands. The presentation is entitled, “Trends in EV Characterization Technologies” – watch it here and please share your own opinions with us by email.
  • Hear directly from the authors of two fascinating papers at our on-demand webinar entitled, “Tick Saliva, COVID and Microfluidic Resistive Pulse Sensing (MRPS).” Learn what these topics have in common by listening here.



New videos in our library

Check frequently for new items in our video library. Our most recent additions include webinar recordings, conference presentations, and how-to tips for efficient nanoparticle analysis with Spectradyne’s microfluidic resistive pulse sensing (MRPS) technology. Happy viewing!