Spectradyne Library

A collection of Spectradyne's literature, notes and presentations.

Refereed journal articles

"A high-throughput label-free nanoparticle analyser."
A publication describing the basic technology on which Spectradyne's unique implementation of resistive pulse sensing is based.
J.-L. Fraikin, T. Teesalu, C.M. McKenney, E. Ruoslahti and A.N. Cleland, Nature Nanotechnology 6, 308-313 (2011).

Trade journal articles

"One size does not fit all: Nanoparticle size analysis for nanomedicine applications."
A publication describing an overview for the application of Spectradyne's nCS1^TM to detection and characterization of nanoparticles in nanomedicine.
A.N. Cleland, J.-L. Fraikin, P. Meinhold, F.M. Monzon, Drug Development and Delivery 6, 20 (April 2016).

"Quantitative nanoparticle analysis based on resistive pulse sensing."
An overview of resistive pulse sensing and its application to nanoparticle analysis.
A.N. Cleland, J.-L. Fraikin, P. Meinhold, F.M. Monzon, American Laboratory, Monday June 20, 2016.

Application notes

Spectradyne's nanoparticle analyzer technology.
Provides an overview description of how Spectradyne's unique microfluidic technology is applied to nanoparticle analysis. (Spectradyne LLC, 2016)

Analysis of extracellular vesicles using the nCS1^TM.
Describes the measurements that can be made to characterize extracellular vesicles using Spectradyne's nanoparticle analysis instrumentation. (Spectradyne LLC, 2016)

A head-to-head comparison: Spectradyne's nCS1^TM vs optical tracking and dynamic light scattering.
Provides an in-depth comparison between resistive pulse sensing, dynamic light scattering, and nanoparticle tracking analysis. (Spectradyne LLC, 2016)

Early detection of protein aggregates with the nCS1^TM.
Spectradyne's nCS1^TM provides an early warning system for protein aggregation through its ability to detect small protein aggregates.(Spectradyne LLC, 2018)

Nanomedicine and synthetic particles for targeted drug delivery.
Applications of the Spectradyne nCS1^TM to the measurement of synthetic nanoparticles to nanomedicine. (Spectradyne LLC, 2016)

Nanoparticle measurements of arbitrarily polydisperse mixtures.
Shows how Spectradyne's technology yields accurate measurements of broad particle distributions, unlike optically-based techniques. (Spectradyne LLC, 2016)

Measurement of all nanoparticle material types.
Discusses how Spectradyne's technology yields materials-independent measurements of nanoparticles made of gold, polystyrene, or other organic and inorganic materials. (Spectradyne LLC, 2016)

Nanoparticle analysis of protein aggregates in biologics.
Shows how Spectradyne's technology can be used to detect protein aggregation in medicine and biology. (Spectradyne LLC, 2016)

The Spectradyne nCS1^TM: Instrument capabilities.
Summary of the instrument specifications for Spectradyne's nCS1^TM. (Spectradyne LLC, 2016)

Measurement of biological nanoparticles: Direct quantification of bacteriophage.
Shows how Spectradyne's microfluidic instrumentation enables the detection and size analysis of individual virus. (Spectradyne LLC, 2016)

Measuring cleanliness of fluids using the nCS1^TM.
Shows how Spectradyne's nCS1^TM can be used to monitor the cleanliness of fluids with very low background counts of nanoparticles. (Spectradyne LLC, 2016)

Technical Briefs

An introduction to microfluidic resistive pulse sensing (MRPS).
We describe the basic concepts and implementation for using resistive pulse sensing (aka Coulter counting) in a microfluidic format. (Spectradyne LLC, 2018)

Where's my peak? Dynamic light scattering vs. resistive pulse sensing.
An objective comparison of resistive pulse sensing and dynamic light scattering, showing how DLS can report incorrect distributions, especially of broad nanoparticle distributions. (Spectradyne LLC, 2018)

DLS results strongly dependent on particle material.
We describe a significant limitation that dynamic light scattering (DLS) suffers from, due to the different optical response of different materials, and how microfluidic resistive pulse sensing (MRPS) is immune to this handicap. (Spectradyne LLC, 2018)

Where's my peak? Nanoparticle tracking analysis vs. resistive pulse sensing.
An objective comparison of resistive pulse sensing and nanoparticle tracking analysis, showing how DLS can report incorrect distributions, especially of broad nanoparticle distributions. (Spectradyne LLC, 2018)

Nanoparticle measurements are unaffected by sample viscosity.
Quantitative measurements of calibration beads in solutions with large differences in viscosity show no discernable difference in particle size or concentration, showing the power of resistive pulse sensing compared to optical techniques. (Spectradyne LLC, 2017)

The nCS1 cartridges are unaffected by aging.
Quantitative calibrations of a set of nCS1 cartridges measured over time show no measurable change in measurement results, indicating that the microfluidic cartriges used in the nCS1 do not degrade with time. (Spectradyne LLC, 2018)

Posters

Analysis of exosome concentration in blastocyst culture media by Microfluidic Resistive Pulse Sensing (MRPS^TM) correlates with embryo implantation capacity: A pilot study
2018 International Society for Extracellular Vesicles ISEV2018 (Barcelona Spain)

Where's my Peak? Separating Truth from Fiction in Label-Free Measurements of EVs
2018 International Society for Extracellular Vesicles ISEV2018 (Barcelona Spain)

Microfluidic Resistive Pulse Sensing (MRPS^TM) validated as a rapid and practical method for evaluating EV enrichment techniques
2018 International Society for Extracellular Vesicles ISEV2018 (Barcelona Spain)

Where's my Peak? Separating Truth from Fiction in Label-Free Measurements of EVs
2018 Circulating Biomarkers World Congress (Boston MA)

Resistive Pulse Sensing (RPS) for High-Resolution Measurement of Polydisperse Nanoparticle Formulations
2017 AAPS National Biotechnology Conference (San Diego CA)

Validation of the Resistive Pulse Sensing Method for Characterizing Nanoparticle Formulations for Drug Delivery
2016 AAPS National Biotechnology Conference (Boston MA)

High Resolution Size and Concentration Analysis of Polydisperse Nanoparticle Mixtures
2015 AAPS National Biotechnology Conference (Los Angeles CA)

High Resolution Nanoparticle Size & Concentration Measurements by Microfluidic Resistive Pulse Sensing
2017 Colorado Protein Stability Workshop (Breckenridge CO)

Validation of Resistive Pulse Sensing for Characterizing Nanoparticles in Drug Formulations
2017 Controlled Release Society (Boston MA)

Measurement of Protein Aggregates in the 150 nm to 1,500 nm Size Range Using Resistive Pulse Sensing
2017 AAPS Northeast Regional Discussion Group (Hartford CT)

A Low-cost Instrument for Rapid Sub-micron Particle Size and Concentration Measurement
2016 NSF Phase II SBIR/STTR Grantees Conference (Atlanta GA)

Validation of the Resistive Pulse Method for Characterizing Nanoparticle Formulations for Drug Delivery
2016 Workshop on Protein Aggregation and Immunogenicity (Breckenridge CO)

Validation of the Resistive Pulse Sensing Method for Characterizing Nanoparticle Formulations for Drug Delivery
2016 International Nanomedicine and Drug Delivery Symposium (Baltimore MD)

High Resolution Size and Concentration Analysis of Polydisperse Nanoparticle Mixtures
2015 American Chemical Society National Meeting (Boston MA)

Webinars

We have developed a comprehensive half-hour webinar introducing our technology. If you are interested in watching this webinar, please register here.

Presentations

The video below is of a presentation given by Lew Brown at the 2017 Precision NanoSystems Symposium in Boston MA.