Refereed journal articles
"An efficient microinjection method to generate human anaplasmosis agent Anaplasma phagocytophilum-infected ticks"
A collaboration between Hameeda Sultana's and Girish Neelakanta's groups at Old Dominion University describe using Spectradyne's nCS1 to generate a human anaplasmosis agent from infected ticks.
V. Taank, E. Ramasamy, H. Sultana, G. Neelakanta, "An efficient microinjection method to generate human anaplasmosis agent
Anaplasma phagocytophilum-infected ticks,"
Sci. Rept. 10, 15994 (2020)
doi.org/10.1038/s41598-020-73061-9
"Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick-Human Skin Interface"
A paper from Hameeda Sultana's group at Old Dominion University describing using Spectradyne's nCS1 as part of a study of exosomes from tick saliva and tick salivary glands.
W. Zhou, F. Tahir, J. C.-Y. Wang, M. Woodson, M. B. Sherman, S. Karim, G. Neelakanta, H. Sultana, "Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick-Human Skin Interface,"
Front. Cell Dev. Biol. 8, 554 (2020)
doi: 10.3389/fcell.2020.00554
"Particle Size Distribution of Bimodal Silica Nanoparticles: A Comparison of Different Measurement Techniques"
A paper from Zoltan Varga's group at the Hungarian Academy of Science describing complementary methods for measuring silica nanoparticles.
M. A. Al-Khafaji, A. Gaal, A. Wacha , A. Bota, Z. Varga, "Particle Size Distribution of Bimodal Silica Nanoparticles: A Comparison of Different Measurement Techniques,"
Materials 13, 3101 (2020)
doi.org/10.3390/ma13143101
"Rapid scale-up and production of active-loaded PEGylated liposomes"
A paper describing use of the nCS1 to characterize liposomes for activated drug delivery.
C. B. Roces, E. C. Port, N. N. Daskalakis, J. A. Watts, J. W. Aylott, G. W. Halbert, Y. Perrie, "Rapid scale-up and production of active-loaded PEGylated liposomes,"
Intl. J. Pharmaceutics 586, 119586 (2020)
doi.org/10.1016/j.ijpharm.2020.119566
"Reagent-free total protein quantification of intact extracellular vesicles by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy"
A paper from Zoltan Varga's group at the Hungarian Academy of Science describes how the Spectradyne's nCS1
TM is used in quantifying extracellular vesicles, combined with infrared spectroscopy.
V. Szentirmai, A. Wacha, C. Nemeth, D. Kitka, A. Racz, K. Heberger, J. Mihaly, Z. Varga, "Reagent-free total protein quantification of intact extracellular vesicles by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy,"
Anal. Bioanal. Chem. (2020)
doi.org/10.1007/s00216-020-02711-8
"Submicrometer, micrometer and visible particle analysis in biopharmaceutical research and development"
A book chapter describing a range of different techniques for characterizing sub-micron, micron-scale and visible particles for pharmaceutical research.
A. Hawe, D. Weinbuch, S. Zolls, A. Reichel, J. F. Carpenter, "Submicrometer, micrometer and visible particle analysis in biopharmaceutical research and development," in
Biophysical Characterization of Proteins in Developing Biopharmaceuticals (Second Edition), (Elsevier 2020) p. 285-310.
doi.org/10.1016/B978-0-444-64173-1.00010-X
"Biophysical analysis of lipidic nanoparticles"
A paper discussing the characterization of lipid nanoparticles.
A. J. Rozoa, M. H. Coxa, A. Devitta, A. J. Rothniea, A. D. Goddard, "Biophysical analysis of lipidic nanoparticles,"
Methods doi.org/10.1016/j.ymeth.2020.05.001
"Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation"
A paper from Zoltan Varga's group at the Hungarian Academy of Science describes how the Spectradyne's nCS1
TM is used in the development of cancer drug-carrying liposomes which are tested in animals.
A. Gaal, T. M. Garay, I. Horvath, D. Mathe, D. Szollosi, D. S. Veres, J. Mbuotidem, T. Kovacs, J. Tovari, R. Bergmann, C. Streli, G. Szakacs, J. Mihaly, Z. Varga, N. Szoboszlai, "Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation,"
Pharmaceutics 12, 466 (2020)
doi.org/10.3390/pharmaceutics12050466
"Size Measurement of Extracellular Vesicles and Synthetic Liposomes: The Impact of the Hydration Shell and the Protein Corona"
A paper from Zoltan Varga's group at the Hungarian Academy of Science and Spectradyne reporting measurements of extracellular vesicles using Spectradyne's nCS1
TM. This paper describes how novel non-optical methods are used to characterize the size of EVs and liposomes. Size measurements from light scattering and microfluidic resistive pulse sensing (MRPS) reveal the thickness of the hydration layer.
Z. Varga, B. Fehera, D. Kitka, A. Wacha, A. Bota, S. Berenyi, V. Pipich, J.-L. Fraikin, "Size Measurement of Extracellular Vesicles and Synthetic Liposomes: The Impact of the Hydration Shell and the Protein Corona,"
Colloids and Surfaces B: Biointerfaces (in press, 2020)
doi.org/10.1016/j.colsurfb.2020.111053
"Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria"
A third-party paper including extracellular vesicle analysis using Spectradyne's nCS1
TM. This paper describes the investigation and measurement of the size and concentration of EVs released by modified ARPE-19 cells with impaired mitochondria, with implications for macular degeneration.
J.Y. Ahn, S. Datta, E. Bandeira, M. Cano, E. Mallick, U. Rai, B. Powell, J. Tian, K.W. Witwer, J.T. Handa, M.E. Paulaitis, "Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria,"
BBA - General Subjects (in press, 2020)
doi: 10.1016/j.bbagen.2020.129598
"Chiral Supraparticles for Controllable Nanomedicine"
A third-party paper including nanoparticle analysis using Spectradyne's nCS1
TM. This paper describes the investigation and measurement of chiral supraparticles with applications to drug delivery systems, tumor detection markers, biosensors, and other biomaterial-based devices.
J. Yeom, P. P. G. Guimaraes, H. M. Ahn, B.-K. Jung, Q. Hu, K. McHugh, M. J. Mitchell, C.-O. Yun, R. Langer, A. Jaklenec, "Chiral Supraparticles for Controllable Nanomedicine,"
Advanced Materials 32, 1903878 (2019)
doi: 10.1002/adma.201903878
"Extracellular Vesicles From Auditory Cells as Nanocarriers for Anti-inflammatory Drugs and Pro-resolving Mediators"
A third-party paper including particle analysis using Spectradyne's nCS1
TM of extracellular vesicles from auditory cells as carriers for drugs and mediators. Provides an excellent discussion of the technology, includes comparisons of MRPS technology to NTA, and MRPS reveals interesting data about the samples.
G. M. Kalinec, L. Gao, W. Cohn, J. P. Whitelegge, K. F. Faull, F. Kalinec, "Extracellular Vesicles From Auditory Cells as Nanocarriers for Anti-inflammatory Drugs and Pro-resolving Mediators,"
Front. Cell. Neurosci. 13, 530 (2019)
doi: 10.3389/fncel.2019.00530
"Contribution of Intravenous Administration Components to Subvisible and Submicron Particles Present in Administered Drug Product"
A third-party paper describing measurement of subvisible and submicron particles and their response to adminstration components.
M. Pollo, A. Mehta, K. Torres, D. Thorne, D. Zimmermann, P. Kolhe, "Contribution of Intravenous Administration Components to Subvisible and Submicron Particles Present in Administered Drug Product,"
J. Pharm. Sci. 108, 2406-2414 (2019)
doi.org/10.1016/j.xphs.2019.02.020
"Detection and phenotyping of extracellular vesicles by size exclusion chromatography coupled with on-line fluorescence detection"
A third-party paper including extracellular vesicle analysis using Spectradyne's nCS1
TM This paper describes the development of a new technology combining size exclusion chromatography (SEC), a commonly used EV purification technique, with fluorescence detection of specifically labeled EVs.
D. Kitka, J. Mihaly, J.-L. Fraikin, T. Beke-Somfai, and Z. Varga, "Detection and phenotyping of extracellular vesicles by size exclusion chromatography coupled with on-line fluorescence detection,"
Sci. Reports 9, 19868 (2019)
doi: 10.1038/s41598-019-56375-1
"Characterisation of particles in solution - a perspective on light scattering and comparative technologies"
A third-party paper using Spectradyne's nCS1 compared to light-scattering techniques to characterize particles in solution.
C. M. Maguire, M. Rosslein, P. Wick, A. Prina-Mello, "Characterisation of particles in solution - a perspective on light scattering and comparative technologies,"
Sci. Tech. Adv. Matls.,
19, 732-745 (2018)
doi:10.1080/14686996.2018.1517587
"Nanosensors for the Chemical Imaging of Acetylcholine Using Magnetic Resonance Imaging"
A third-party paper using Spectradyne's nCS1 to characterize the concentration of nanoparticles to be used as nanosensors.
Y. Luo, E. H. Kim, C. A. Flask, H. A. Clark, "Nanosensors for the Chemical Imaging of Acetylcholine Using Magnetic Resonance Imaging,"
ACS Nano 12, 5761-5773 (2018)
doi: 10.1021/acsnano.8b01640
"Critical evaluation of microfluidic resistive pulse sensing for quantification and sizing of nanometer- and micrometer-sized particles in biopharmaceutical products"
A third-party paper evaluating resistive pulse sensing for particle analysis in pharmaceutical applications.
A. D. Grabarek, D. Weinbuch, W. Jiskoot, A. Hawe,
J. Pharm. Sci. 108, 563-573 (2018)
doi: 10.1016/j.xphs.2018.08.020
"Submicron Protein Particle Characterization using Resistive Pulse Sensing and Conventional Light Scattering Based Approaches"
A third-party paper comparing resistive pulse sensing and conventional light scattering for sub-micron protein particles.
G. V. Barnett, J. M. Perhacs, T. K. Das, S. R. Kar,
Pharm. Res. 35, 58 (2018)
doi: 10.1007/s11095-017-2306-0
"Hollow organosilica beads as reference particles for optical detection of extracellular vesicles"
A publication describing the calibration of hollow organosilica beads as references for extracellular vesicle characterization.
Z. Varga, E. Van Der Pol, M. Palmai, R. Garcia-Diez, C. Gollwitzer, M. Krumrey, J.-L. Fraikin, A. Gasecka, N. Hajji, T. G. Van Leeuwen, R. Nieuwland,
J. Thrombosis and Haeomostasis 16, 1646-1655 (2018)
doi: 10.1111/jth.14193
"Size and concentration determination of extracellular vesicles as small as 50 nm in diameter at a rate beyond 10,000 EV/s"
A symposium presentations describing the use of Spectradyne's nCS1 for evaluating extracellular vesicles.
J.-L. Fraikin, L. de Rond, C. Hau, F. Monzon, E. van der Pol,
ISEV 2017 proceedings, May 17, 2017.
https://search.proquest.com/openview/892d4921e65a6105e2cc30919e5104dd/1?pq-origsite=gscholar&cbl=2030046
"A high-throughput label-free nanoparticle analyser."
A publication describing the basic technology on which Spectradyne's unique implementation of resistive pulse sensing is based.
J.-L. Fraikin, T. Teesalu, C.M. McKenney, E. Ruoslahti and A.N. Cleland,
Nature Nanotechnology 6, 308-313 (2011)
doi: 10.1038/nnano.2011.24
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